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研究项目(一)study projects-1

  访问量:[708]  发布日期:[2016-11-28 16:02:03]

研究项目(一)study projects-1

研究项目:

第一部分:基础理论研究
1. THEORETICAL RESEARCHES

1、上海市男性生殖与泌尿疾病药物非临床评价专业技术服务平台
Shanghai professional technical service platform of non-clinical evaluation of Male reproductive and urinary drugs

2、基于动物福利的卵巢功能早衰动物模型替代技术的创建和应用
Establishment and application of alternative technology of animal model of premature ovarian failure based on animal welfare

3、DC037042抑制老年Beagle犬体内外苯肾上腺素样活性探索性研究
Exploratory research on inhibition of DC037042 on phenylephrine-like activity in aged Beagle dogs in vitro and in vivo

4、ZY-Z001非临床体内外肝脏毒性探索研究
Exploratory study on the preclinical liver toxicity of ZY-Z001 in vivo and in vitro

5、雌(雄)激素改变大鼠前列腺组织培养环境中的上皮和纤维细胞生物学特征研究
Study on biology characteristics of epithelial and fiber cell of rats prostatic tissue in estrogen or androgen changed culture environment.

6、雌(雄)激素改变共培养环境中的人上皮和纤维细胞生物学特征研究
Study on biology characteristics of hunman epithelial and fiber cell in estrogen or androgen changed co-culture environment.

7、雌(雄)激素诱导大鼠前列腺炎模型中腺体分子生物学特征研究
Study on molecular biology characteristics of gland in the model of prostatitis induced by estrogen or androgen.

8、大鼠前列腺炎激发因子(途径)探索性研究
Exploratory research on the prostatitis stimulative factors (routes) in rats.

9、探索建立生殖毒性伴随毒代动力学研究体系
Establishment of the study system of reproductive toxicity accompanied by toxicokinetic.

10、小鼠腔前卵泡体外培养技术的建立和检测方法的优化
Establishment of the culture techniques of mice preantral follicles in vitro and optimization of the detection method.

11、宫颈癌裸鼠原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) cervical cancer and the study of new biomarkers in nude mice

12、乳腺癌裸鼠原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) mammary cancer and the study of new biomarkers in nude mice

13、卵巢癌裸鼠原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) oophoroma and the study of new biomarkers in nude mice

14、子宫内膜腺癌原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) endometrial adenocarcinoma and the study of new biomarkers in nude mice

15、豚鼠子宫肌瘤的模型建立及其新生物标志物的研究
Establishment of hysteromyoma model and the study of new biomarkers in guinea pig

16、睾丸癌裸鼠原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) testicular cancer and the study of new biomarkers in nude mice

17、前列腺癌裸鼠原位(或转移)移植瘤的模型建立及其新生物标志物的研究
Establishment of transplanted tumors model of the orthotopic (or metastatic) prostatic cancer and the study of new biomarkers in nude mice

18、生殖系统肿瘤动物病理背景数据库的建立
Establishment of animal pathologic background database of tumors in the reproductive system

19、《生殖系统肿瘤比较学组织图谱》的编制
Preparation of “comparative study of figures of tumor tissues in the reproductive system”

20、SD大鼠血清低温冷冻时间对主要性激素含量测定的影响
Effects of serum frozen time of SD rats on the determination of main sex hormone

21、不同检测系统对动物血清中主要性激素含量测定的影响
Effects of detecting system on the determination of main sex hormone in animal serum

22、丙基硫氧嘧啶SD大鼠灌胃围产期毒性试验
Perinatal toxicity test of propylthiouracil in SD rats

23、建立并完善IL-1β诱导的大鼠体外前列腺上皮细胞前列腺炎模型
Establishing and perfecting IL-1β—induced prostatitis model in vivo with rats

24、JH10提取物抗大鼠阴道炎及宫颈炎有效性筛选开发研究
Study on Validity of JH10 series extracts against vaginitis and cervicitis in SD rats

25、符合国际规范小鼠淋巴瘤细胞体外细胞突变试验体系的建立和应用
Establishment and application of the mutation test of mouse lymphoma cells in vitro in accordance with international standards

26、符合国际规范IVOS精子分析系统的建立和应用
Establishment and application of the system of IVOS sperm assay in accordance with international standards

27、符合国际规范动物睾丸Davidson's或NBF- Bouin's固定法的建立和应用
Establishment and application of the Davidson's or NBF- Bouin's fixation of animal testis in accordance with international standards

28、符合国际规范生殖毒代动力学体系的建立和应用
Establishment and application of the reproductive toxicokinetic system in accordance with international standards

29、符合国际规范雄性生殖系统毒性评价体系的建立和应用
Establishment and application of toxtic evaluation system of the male reproductive system in accordance with international standards

30、符合国际规范围产期毒性试验方法学研究
Methodology on Perinatal toxicity test in accordance with international standards

31、符合国际规范致癌性技术体系的建立和应用
Establishment and application of the carcinogenic technique system in accordance with international standards

32、符合国际规范高通量遗传毒性筛选评价模型的建立和应用
Establishment and application of evaluation model of the high throughout screening of genotoxicology in accordance with international standards

33、符合国际规范化学致畸物的体外评价模型的建立和应用
Establishment and application of evaluation model of the chemical teratogens in vitro in accordance with international standards

34、符合国际规范雄性动物生殖相关细胞单独及共同培养系统的建立和应用
Establishment and application of the system of the related male reproductive cells pure culture and co-culture in accordance with international standards

35、符合国际规范雌性动物生殖相关细胞单独及共同培养系统的建立和应用
Establishment and application of the system of the related female reproductive cells pure culture and co-culture in accordance with international standards

36、符合国际规范肝脏毒性药物早期筛选新技术和新模型的建立和应用
Establishment and application of the new teckniques and models screening of drug hepatic toxicology in an early stage in accordance with international standards

37、符合国际规范肾脏毒性药物早期筛选新技术和新模型的建立和应用
Establishment and application of the new teckniques and models screening of drug renal toxicology in an early stage in accordance with international standards

38、符合国际规范心脏毒性药物早期筛选新技术和新模型的建立和应用
Establishment and application of the new teckniques and models screening of drug cardiac toxicology in an early stage in accordance with international standards

39、符合国际规范前列腺毒性药物早期筛选新技术和新模型的建立和应用
Establishment and application of the new teckniques and models screening of drug prostate toxicology in an early stage in accordance with international standards

40、符合国际规范“计数膜”法的建立和应用
Establishment and application of the method of count-membrane in accordance with international standards

41、建立符合国际规范的毒性病理背景数据库
Establishment of toxic pathology background database in accordance with international standards

42、符合国际规范远程诊断系统的构建和应用
Establishment of remote diagnosis system in accordance with international standards

43、符合国际规范遥测技术的建立和应用
Establishment of telemetry technology in accordance with international standards

44、中药安全性和过敏原性新技术的建立和应用
Establishment and application of the new teckniques to detect the safety and allergy of traditional chinese medicine in accordance with international standards

45、采用流式细胞技术,建立符合国际规范的免疫毒性新模型
Establishment of the new model of immune toxicity by flow cytometry in accordance with international standards

46、符合国际规范的实验室信息与数据管理系统建立和应用
Establishment of of laboratory information and data management system in accordance with international standards

47、雄性SD大鼠长期给予非那雄胺的生殖毒性机制研究
Study on the mechanism of the reproductive toxicology of long term administration of finasteride in male SD rats

48、啤酒花对雄性大鼠精子的影响
Influence of humulus lupulus on sperms of male rats

49、基于GLP的中药注射剂过敏反应特异性模型研究
Study on the specific model of allergic reaction of TCM injection based on GLP

50、灯盏花素毒代动力学研究中血药浓度检测方法学比较研究
Comparative study on determination of erigeron in plasma of toxicokinetic study

51、常见实验动物血液学和生化指标背景数据的建立
Establishment of the background database of hematological and biochemical parameters of common animals in accordance with international standards

52、常见实验动物血凝指标背景数据的建立
Establishment of the background database of hemostatic parameters of common animals in accordance with international standards

53、常见实验动物激素背景数据的建立
Establishment of the background database of hormone parameters of common animals in accordance with international standards

54、常见实验动物生理学体征指标背景数据的建立
Establishment of the background database of physiological signs of common animals in accordance with international standards

55、常见实验动物生理学功能性指标背景数据的建立
Establishment of the background database of physiological functional parameters of common animals in accordance with international standards

56、环境内分泌干扰物双酚A与前列腺增生关系探索
Study on the relationship of endocrine-disrupting chemical BPA and BPH

57、建立符合国际新药研究规范的临床前安全评价技术平台
Establishing technology platform for preclinical evaluation on new drug in accordance with international standards

58、用于杀灭爱滋病病毒和精子的阴道栓剂临床前研究
The preclinical study on pessary for killing HIV and sperm

59、建立并完善抗前列腺疾病药物临床前评价技术服务平台
Establishing and perfecting technology platform for preclinical evaluation of anti-prostate disease drug

60、替代前列腺疾病动物实验方法规范技术平台的建立及应用
Establishment and application of standardized technology platform for alternative method of Animals with prostate disease experiment

61、建立和完善前列腺疾病模型及其效果评价体系
Establishing and perfecting the evaluation system of prostate disease model and its effectiveness

62、引进美国新药安全性评价技术,建立符合国际规范的评价体系
Introducing safety evaluation technology on new drugs of USA, establishing evaluation system in accordance with international standards

63、消避灵阴道栓临床前研究
The preclinical study on Xiaobiling pessary

64、前列腺癌前病变分子生物学基础研究
Molecular biological basic study on the precancerosis of prostate cancer

65、良性前列腺增生体外筛药模型及Beagle狗药效学模型建立
Establishing the models of drugs screening for anti-BPH in vitro and in vivo with Beagle dogs

66、甾体5a-还原酶抑制剂分子生物学生殖毒性研究
The molecular biological study on reproductive toxicity of steroid 5α-reductase inhibitors

67、子宫内膜异位食蟹猴模型的建立
Establishment of endometriosis model of cynomolgus monkeys

68、转移性前列腺癌食蟹猴模型的建立
Establishment of metastatic prostate cancer model of cynomolgus monkeys

69、皮下注射睾丸酮和雌二醇对食蟹猴前列腺腺体影响的研究
Study on effects of the subcutaneous injection of testosterone and estradiol on the prostate glands of cynomolgus monkey

70、治疗前列腺疾病抗体偶联药物开发研究
Development study on drug conjugated with antibody against prostate disease

71、借助数学模型揭示雌、雄激素比例变化引发前列腺增生的规律
Study on the mechanism of benign prostatic hyperplasia induced by androgen-estrogen ratio with mathematics model

72、前列腺增生(良性、恶性)机制探索性研究
Exploratory study on the mechanism of prostatic hyperplasia (benign, malignant)

73、出生缺陷机制探索性研究
Exploratory study on the mechanism of birth defect

74、寻找诊断新西兰兔早早孕金指标的研究
Study on diagnostic golden index of New Zealand rabbits in early pergnancy


 

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