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研究项目(六)study projects-6

  访问量:[621]  发布日期:[2016-11-25 16:27:50]

研究项目(六)study projects-6

3、利用食蟹猴进行的研究
Study with cynomolgus macaques

(1)阿达木单抗食蟹猴皮下注射三个月长期毒性伴随毒代动力学、免疫原性、血管、肌肉和皮肤刺激试验
Chronic toxicity test of adalimumab injection by subcutaneous injection accompany with toxicokinetics, immunogenicity, blood, vessels, muscles, and skin irritation test in cynomolgus macaques for three months

(2)注射用重组人促卵泡激素食蟹猴皮下注射3个月长期毒性试验
Chronic toxicity test of rhFSH injection by subcutaneous injection in cynomolgus macaques for three months

(3)聚乙二醇化重组人干扰素α-2b食蟹猴皮下注射(sc)长期毒性试验
Chronic toxicity study on PEG-IFN-α-2b by subcutaneous injection in cynomolgus macaques

(4)重组抗CD20人鼠嵌合单克隆抗体食蟹猴静脉注射(iv)3个月长期毒性试验
Chronic toxicity study on recombinant human/mouse chimeric anti-CD20 monoclonal antibody by intravenous injection in cynomolgus macaques for three months

(5)聚乙二醇重组人生长激素食蟹猴皮下注射(sc)9个月长期毒性试验
Chronic toxicity study on PEG-hGH by subcutaneous injection in cynomolgus macaques for nine months

(6)重组抗CD3人鼠嵌合单克隆抗体食蟹猴静脉注射(iv)3个月长期毒性试验
Chronic toxicity study on recombinant human/mouse chimeric anti-CD3 monoclonal antibody by intravenous injection in cynomolgus macaques for three months

(7)长效干扰素食蟹猴皮下注射(sc)9个月长期毒性试验
Chronic toxicity study on long-acting interferon by subcutaneous injection in cynomolgus macaques for nine months

(8)重组抗Ig E人源化单克隆抗体食蟹猴静脉注射(iv)3个月长期毒性试验
Chronic toxicity study on recombinant anti-IgE humanized monoclonal antibody by intravenous injection in cynomolgus macaques for three months

(9)重组抗TNF人鼠嵌合化单克隆抗体食蟹猴静脉注射(iv)长期毒性试验
Chronic toxicity study on recombinant human/mouse chimeric anti-TNF monoclonal antibody by intravenous injection in cynomolgus macaques

(10)重组抗CD25人鼠嵌合化单克隆抗体食蟹猴静脉注射(iv)3个月长期毒性试验
Chronic toxicity study on recombinant human/mouse chimeric anti-CD25 monoclonal antibody by intravenous injection in cynomolgus macaques for three months

(11)聚乙二醇化天花粉蛋白食蟹猴静脉注射(iv)9个月长期毒性试验
Chronic toxicity study on PEG-trichosanthin by intravenous injection in cynomolgus macaques for nine months

(12)天花粉蛋白食蟹猴静脉注射(iv)3个月长期毒性试验
Chronic toxicity study on trichosanthin by intravenous injection in cynomolgus macaques for three months

(13)长效孕三烯酮微球注射剂食蟹猴皮下注射(sc)9个月长期毒性试验
Chronic toxicity study on long-acting gestrinone microspheres injection by subcutaneous injection in cynomolgus macaques for nine months

(14)重组人白细胞介素-1受体拮抗剂恒河猴皮下注射(sc)9个月长期毒性试验
Chronic toxicity study on recombinant hunman IL-1 antagonist by subcutaneous injection in Rhesus Monkey for nine months

四、遗传毒性试验
Genetic Toxicity Test

1、Ames试验
Ames Test

(1)CT-1139 Ames试验
Ames test of CT-1139

(2)雄地那非Ames试验
Ames test of Xiongdinafei

(3)NCP4 Ames试验
Ames test of NCP4

(4)YF-49-92.MLS Ames试验
Ames test of YF-49-92.MLS

(5)苯磷硫胺Ames毒性试验
Ames test of benfotiamine

(6)注射用灯盏花素Ames试验
Ames test of erigeron injection

(7)碘化油乙酯注射液Ames试验
Ames test of iodinate oil injection

(8)芒柄花素磺酸钠Ames毒性试验
Ames test of formononetin

(9)重组人表皮生长因子Ames试验
Ames test of rhEGF

(10)聚乙二醇化重组人干扰素α-2b Ames试验
Ames test of PEG-IFN-α-2b

(11)落新妇苷(ND702)Ames试验
Ames test of astilbin(ND702)

(12)迷迭香酸(ND701)Ames试验
Ames test of rosmarinic acid (ND701)

(13)聚乙二醇重组人生长激素Ames试验
Ames test of PEG-hGH

(14)黄芪甲苷致突变毒性之Ames试验
Ames test of astragaloside

(15)20(S)-人参皂苷Rg3 Ames试验
Ames test of 20(S)-ginsenoside

(16)丹参素钠Ames试验
Ames test of Danshensu-Sodium

(17)长效干扰素Ames试验
Ames test of long-acting interferon

(18)聚乙二醇化天花粉蛋白致突变试验之Ames试验
Ames test of PEG-trichosanthin

(19)AWA静脉注射液Ames试验
Ames test of AWA injection

(20)阿地福韦双特戊酰氧基甲酯致突变试验之Ames试验
Ames test of adefovir dipivixil

2、微核试验
Micronucleus Test

(1)CT-1139小鼠灌胃微核试验
Micronucleus test of CT-1139 by intragastric administration in mice

(2)雄地那非小鼠灌胃微核试验
Micronucleus test of Xiongdinafei by intragastric administration in mice

(3)NCP4小鼠静脉注射微核试验
Micronucleus test of NCP4 by intravenous injection in mice

(4)YF-49-92.MLS 小鼠灌胃微核试验
Micronucleus test of YF-49-92.MLS by intragastric administration in mice

(5)苯磷硫胺微核毒性试验
Micronucleus test of benfotiamine

(6)注射用灯盏花素小鼠静脉给药微核试验
Micronucleus test erigeron injection by intravenous administration in mice.

(7)碘化油乙酯注射液小鼠静脉给药微核试验
Micronucleus test of iodinate oil injection by intravenous administration in mice

(8)芒柄花素磺酸钠微核毒性试验
Micronucleus test of formononetin

(9)注射用头孢他美钠小鼠静脉给药微核试验
Micronucleus test of cefetamet sodium injection by intravenous administration in mice

(10)重组人表皮生长因子微核试验
Micronucleus test of rhEGF

(11)聚乙二醇化重组人干扰素α-2b ICR小鼠皮下注射(sc)微核试验
Micronucleus test of PEG-IFN-α-2b by subcutaneous injection in mice

(12)落新妇苷(ND702)ICR小鼠灌胃(ig)微核试验
Micronucleus test of astilbin (ND702) by intragastric administration in mice

(13)迷迭香酸(ND701)ICR小鼠灌胃(ig)微核试验
Micronucleus test of rosmarinic acid (ND701) by intragastric administration in mice

(14)聚乙二醇重组人生长激素ICR小鼠皮下注射(sc)微核试验
Micronucleus test of PEG-hGH by subcutaneous injection in ICR mice

(15)黄芪甲苷致突变毒性之ICR小鼠皮下注射(sc)微核试验
Micronucleus test of astragaloside by subcutaneous injection in ICR mice

(16)20(S)-人参皂苷Rg3ICR小鼠灌胃(ig)微核试验
Micronucleus test of 20(S)-ginsenoside Rg3 by intragastric administration in ICR mice

(17)丹参素钠ICR小鼠静脉注射(iv)微核试验
Micronucleus test of Danshensu-Sodium by intravenous injection in ICR mice

(18)长效干扰素ICR小鼠皮下注射(sc)微核试验
Micronucleus test of long-acting interferon by subcutaneous injection in ICR mice

(19)聚乙二醇化天花粉蛋白致突变试验之ICR小鼠静脉注射(iv)微核试验
Micronucleus test of PEG-trichosanthin by intravenous injection in ICR mice

(20)AWA静脉注射液ICR小鼠静脉注射(iv)微核试验
Micronucleus test of AWA injection by intravenous injection in ICR mice

(21)阿地福韦双特戊酰氧基甲酯致突变试验之ICR小鼠灌胃(ig)微核试验
Micronucleus test of adefovir dipivixil by intragastric administration in ICR mice

3、染色体畸变试验
Chromosome Aberration Test

(1)CT-1139染色体畸变试验
Chromosome aberration test of CT-1139

(2)雄地那非染色体畸变试验
Chromosome aberration test of Xiongdinafei

(3)NCP4染色体畸变试验
Chromosome aberration test of NCP4

(4)YF-49-92.MLS 染色体畸变试验
Chromosome aberration test of YF-49-92.MLS

(5)苯磷硫胺染色体畸变毒性试验
Chromosome aberration test of benfotiamine

(6)注射用灯盏花素染色体畸变试验
Chromosome aberration test of erigeron injection

(7)碘化油乙酯注射液染色体畸变试验
Chromosome aberration test of iodinate oil injection

(8)芒柄花素磺酸钠染色体畸变毒性试验
Chromosome aberration test of formononetin

(9)注射用头孢他美钠染色体畸变试验
Chromosome aberration test of cefetamet sodium injection

(10)重组人表皮生长因子染色体畸变试验
Chromosome aberration test of rhEGF

(11)聚乙二醇化重组人干扰素α-2b染色体畸变试验
Chromosome aberration test of PEG-IFN-α-2b

(12)落新妇苷(ND702)染色体畸变试验
Chromosome aberration test of astilbin (ND702)

(13)迷迭香酸(ND701)染色体畸变试验
Chromosome aberration test of rosmarinic acid (ND701)

(14)聚乙二醇重组人生长激素染色体畸变试验
Chromosome aberration test of PEG-rGH

(15)黄芪甲苷致突变毒性之染色体畸变试验
Chromosome aberration test of astragaloside

(16)20(S)-人参皂苷Rg3染色体畸变试验
Chromosome aberration test of 20(S)-ginsenoside Rg3

(17)丹参素钠染色体畸变试验
Chromosome aberration test of Danshensu-Sodium

(18)长效干扰素染色体畸变试验
Chromosome aberration test of long-acting interferon

(19)聚乙二醇化天花粉蛋白致突变试验之染色体畸变试验
Chromosome aberration test of PEG-trichosanthin

(20)AWA静脉注射液染色体畸变试验
Chromosome aberration test of AWA injection


 

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